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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Peptidyl-prolyl cis-trans isomerase A | ||
| Ligand | BDBM50037809 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51869 (CHEMBL665880) | ||
| IC50 | 2.3±n/a nM | ||
| Citation |  Papageorgiou, C; Florineth, A; Mikol, V Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain. J Med Chem37:3674-6 (1994) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Peptidyl-prolyl cis-trans isomerase A | |||
| Name: | Peptidyl-prolyl cis-trans isomerase A | ||
| Synonyms: | CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A | ||
| Type: | Protein | ||
| Mol. Mass.: | 18015.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P62937 | ||
| Residue: | 165 | ||
| Sequence: |
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| BDBM50037809 | |||
| n/a | |||
| Name | BDBM50037809 | ||
| Synonyms: | (R)-30-Ethyl-33-((E)-(1R,2R)-1-hydroxy-2-methyl-hex-4-enyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-24-((S)-2-methyl-butyl)-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone | CHEMBL2375162 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C63H113N11O12 | ||
| Mol. Mass. | 1216.6378 | ||
| SMILES | [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C[C@@H](C)CC)N(C)C(=O)CN(C)C(=O)C(CC)NC1=O)C(C)C | ||
| Structure | 
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