| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil elastase |
|---|
| Ligand | BDBM50280676 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_64660 (CHEMBL674812) |
|---|
| KON | 1.9 M-1s-1 |
|---|
| Citation |  Alpegiani, M; Bissolino, P; Corigli, R; Del Nero, S; Perrone, E; Rizzo, V; Sacchi, N; Cassinelli, G; Franceschi, G; Baici, A Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-Methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones. J Med Chem37:4003-19 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil elastase |
|---|
| Name: | Neutrophil elastase |
|---|
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28532.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08246 |
|---|
| Residue: | 267 |
|---|
| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
|---|
| BDBM50280676 |
|---|
| n/a |
|---|
| Name | BDBM50280676 |
|---|
| Synonyms: | (6R,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-5,5-dioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-en-8-one | CHEMBL14827 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H21N5O5S2 |
|---|
| Mol. Mass. | 415.488 |
|---|
| SMILES | CO[C@@H]1[C@@H]2N(C1=O)C(C(=O)C(C)(C)C)=C(CSc1nnnn1C)CS2(=O)=O |t:14| |
|---|
| Structure | 
|
|---|
Search and Browse
