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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 1 | ||
| Ligand | BDBM50038907 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_28505 (CHEMBL645934) | ||
| IC50 | 21.7±n/a nM | ||
| Citation |  Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem37:2079-84 (1994) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 1 | |||
| Name: | Sterol O-acyltransferase 1 | ||
| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 64165.56 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_28796 | ||
| Residue: | 545 | ||
| Sequence: |
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| BDBM50038907 | |||
| n/a | |||
| Name | BDBM50038907 | ||
| Synonyms: | 1-(2,4-Difluoro-phenyl)-3-(6-methyl-4-o-tolyl-quinolin-3-yl)-urea | CHEMBL413330 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H19F2N3O | ||
| Mol. Mass. | 403.424 | ||
| SMILES | Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1 |(3.34,-3.16,;4.67,-2.39,;4.67,-.84,;6,-.05,;7.35,-.84,;8.66,-.05,;10.01,-.82,;10.02,-2.36,;11.35,-3.13,;12.68,-2.36,;12.68,-.82,;14.02,-3.13,;14.03,-4.67,;12.7,-5.44,;12.7,-6.98,;14.05,-7.73,;14.05,-9.27,;15.38,-6.95,;15.36,-5.42,;16.69,-4.63,;8.69,-3.15,;8.69,-4.69,;10.03,-5.44,;10.02,-6.98,;8.69,-7.75,;7.35,-6.98,;7.35,-5.44,;6.02,-4.67,;7.35,-2.38,;6.02,-3.13,)| | ||
| Structure | 
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