| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Collagenase 3 |
|---|
| Ligand | BDBM50493275 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_983461 (CHEMBL2429271) |
|---|
| IC50 | 0.040000±n/a nM |
|---|
| Citation |  Hugenberg, V; Riemann, B; Hermann, S; Schober, O; Schäfers, M; Szardenings, K; Lebedev, A; Gangadharmath, U; Kolb, H; Walsh, J; Zhang, W; Kopka, K; Wagner, S Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation. J Med Chem56:6858-70 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Collagenase 3 |
|---|
| Name: | Collagenase 3 |
|---|
| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53808.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P45452 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
|
|
|
|---|
| BDBM50493275 |
|---|
| n/a |
|---|
| Name | BDBM50493275 |
|---|
| Synonyms: | CHEMBL2425941 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H20FN3O5S |
|---|
| Mol. Mass. | 373.4 |
|---|
| SMILES | CC(C)[C@@H](N(CC#N)S(=O)(=O)c1ccc(OCCF)cc1)C(=O)NO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
