| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50039547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162034 (CHEMBL766674) |
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| IC50 | 51±n/a nM |
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| Citation |  Niwas, S; Chand, P; Pathak, VP; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines. J Med Chem37:2477-80 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Np | PNPH_RAT | Pnp | Purine nucleoside phosphorylase | Purine-nucleoside phosphorylase | nucleoside phosphorylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32303.61 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_162034 |
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| Residue: | 289 |
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| Sequence: | MENEFTYEDYQRTAEWLRSHTKHRPQVAVICGSGLGGLTAKLTQPQAFDYNEIPNFPQST
VQGHAGRLVFGFLNGRSCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFNAWKQ
MGEQRELQEGTYIMSAGPTFETVAESCLLRMLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVVMDYNNLEKASHQEVLEAGKAAAQKLEQFVSILMESIPPRERAN
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| BDBM50039547 |
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| n/a |
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| Name | BDBM50039547 |
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| Synonyms: | 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL310202 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N4O |
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| Mol. Mass. | 240.2606 |
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| SMILES | Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 |
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| Structure | 
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