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TargetVesicular acetylcholine transporter
LigandBDBM50039627
Substrate/Competitorn/a
Meas. Tech.ChEMBL_213554
Ki 0.264±n/a nM
Citation Efange SMKhare ABFoulon CAkella SKParsons SM Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function. J Med Chem 37:2574-82 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Vesicular acetylcholine transporter
Name:Vesicular acetylcholine transporter
Synonyms:TorVAChT | VAChT
Type:PROTEIN
Mol. Mass.:56111.93
Organism:Torpedo californica
Description:ChEMBL_1503355
Residue:515
Sequence:
MGVTMAVGLAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVI
VPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAI
LQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAVLFAARSLQGLGSAFAD
TSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCL
LDGILLLMVVTPFASRTRENMLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNW
MKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWFYGAVGLVIIGASSCTIP
ACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALG
PIMAGQIVHDLGFVQLNLGMGLVNILYAPALLFLRNVCQMKPSLSERNILLEEGPKGLYD
TIIMEERKAAKEPHGSSSGNHSVHAVLSDQEGYSE
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  Blast E-value cutoff:
BDBM50039627
n/a
NameBDBM50039627
Synonyms:1-(3-iodobenzyl)-3-spiro[1H-indene-1,4'-(hexahydropyridine)]-1-yl-(3R,4R)-hexahydro-4-pyridinol | CHEMBL86983
TypeSmall organic molecule
Emp. Form.C25H29IN2O
Mol. Mass.500.415
SMILESO[C@@H]1CCN(Cc2cccc(I)c2)C[C@H]1N1CCC2(CC1)C=Cc1ccccc21 |c:24|
Structure
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