| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol 14-alpha demethylase |
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| Ligand | BDBM50493550 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_984872 (CHEMBL2432695) |
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| Kd | <5.0±n/a nM |
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| Citation |  Choi, JY; Calvet, CM; Gunatilleke, SS; Ruiz, C; Cameron, MD; McKerrow, JH; Podust, LM; Roush, WR Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. J Med Chem56:7651-68 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol 14-alpha demethylase |
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| Name: | Sterol 14-alpha demethylase |
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| Synonyms: | CP51_TRYCC | CYP51 | Cytochrome P450 51 | Lanosterol 14-alpha demethylase | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase | Sterol 14-alpha demethylase (CYP51) | Tc14DM |
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| Type: | Protein |
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| Mol. Mass.: | 54690.12 |
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| Organism: | Trypanosoma cruzi |
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| Description: | Q7Z1V1 |
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| Residue: | 481 |
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| Sequence: | MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCK
RDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPY
PRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTAC
QCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKIL
GEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITT
SWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVM
RMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVH
KCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLP
S
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| BDBM50493550 |
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| n/a |
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| Name | BDBM50493550 |
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| Synonyms: | CHEMBL2431645 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N4O2 |
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| Mol. Mass. | 426.5102 |
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| SMILES | O=C(CCCc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccncc1 |r| |
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| Structure | 
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