| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 5B, mitochondrial |
|---|
| Ligand | BDBM35733 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_992706 (CHEMBL2443608) |
|---|
| Ki | 10.0±n/a nM |
|---|
| Citation |  Güzel-Akdemir, O; Biswas, S; Lastra, K; McKenna, R; Supuran, CT Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. Bioorg Med Chem21:6674-80 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 5B, mitochondrial |
|---|
| Name: | Carbonic anhydrase 5B, mitochondrial |
|---|
| Synonyms: | CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36440.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human (cloned) isozyme |
|---|
| Residue: | 317 |
|---|
| Sequence: | MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPG
GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPL
EHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVI
GVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLS
ESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
|
|
|
|---|
| BDBM35733 |
|---|
| n/a |
|---|
| Name | BDBM35733 |
|---|
| Synonyms: | sulfonamide deriv., 7a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14N2O3S |
|---|
| Mol. Mass. | 290.338 |
|---|
| SMILES | NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
