| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
|---|
| Ligand | BDBM50040680 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_50198 (CHEMBL663491) |
|---|
| IC50 | 6.16±n/a nM |
|---|
| Citation |  Bock, MG; DiPardo, RM; Mellin, EC; Newton, RC; Veber, DF; Freedman, SB; Smith, AJ; Patel, S; Kemp, JA; Marshall, GR Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility. J Med Chem37:722-4 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholecystokinin receptor type A |
|---|
| Name: | Cholecystokinin receptor type A |
|---|
| Synonyms: | CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49676.37 |
|---|
| Organism: | RAT |
|---|
| Description: | Cholecystokinin central 0 RAT::P30551 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP
|
|
|
|---|
| BDBM50040680 |
|---|
| n/a |
|---|
| Name | BDBM50040680 |
|---|
| Synonyms: | 1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-[4-(1H-tetrazol-5-yl)-phenyl]-urea | CHEMBL423472 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H20N8O2 |
|---|
| Mol. Mass. | 452.468 |
|---|
| SMILES | CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(cc2)-c2nnn[nH]2)C1=O)c1ccccc1 |c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
