| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50039552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162190 (CHEMBL766710) |
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| Ki | 210±n/a nM |
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| Citation |  Guida, WC; Elliott, RD; Thomas, HJ; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Ealick, SE; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics. J Med Chem37:1109-14 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50039552 |
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| n/a |
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| Name | BDBM50039552 |
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| Synonyms: | CHEMBL267312 | [3,3-Dimethyl-5-(6-oxo-1,6-dihydro-purin-9-yl)-pentyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19N4O4P |
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| Mol. Mass. | 314.2774 |
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| SMILES | CC(C)(CCn1cnc2c1nc[nH]c2=O)CCP(O)(O)=O |
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| Structure | 
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