Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM906 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_159974 (CHEMBL768121) |
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Ki | 5370±n/a nM |
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Citation | Reddy, MR; Varney, MD; Kalish, V; Viswanadhan, VN; Appelt, K Calculation of relative differences in the binding free energies of HIV1 protease inhibitors: a thermodynamic cycle perturbation approach. J Med Chem37:1145-52 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM906 |
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n/a |
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Name | BDBM906 |
Synonyms: | (4S,5S)-5-[(2S)-2-[(2S)-2-aminopropanamido]propanamido]-N-[1H-1,3-benzodiazol-2-yl(phenyl)methyl]-4-hydroxy-6-phenylhexanamide | 5-(L-Alanyl-L-alanylamino)-4-hydroxy-phenylhexanoic Acid ((1H-BenzimiaazOl-2-yl)phenylmethyl)amide | C-terminal inhibitor 4 | CHEMBL15049 |
Type | Small organic molecule |
Emp. Form. | C32H38N6O4 |
Mol. Mass. | 570.6819 |
SMILES | C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CCC(=O)NC(c1nc2ccccc2[nH]1)c1ccccc1 |r| |
Structure |
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