Reaction Details |
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Target | Tubulin beta chain |
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Ligand | BDBM50494617 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1278981 (CHEMBL3097627) |
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IC50 | 16000±n/a nM |
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Citation | Nakamura, M; Kajita, D; Matsumoto, Y; Hashimoto, Y Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker. Bioorg Med Chem21:7381-91 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tubulin beta chain |
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Name: | Tubulin beta chain |
Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
Type: | PROTEIN |
Mol. Mass.: | 49840.26 |
Organism: | Sus scrofa |
Description: | ChEMBL_105107 |
Residue: | 445 |
Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
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BDBM50494617 |
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n/a |
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Name | BDBM50494617 |
Synonyms: | CHEMBL3093548 |
Type | Small organic molecule |
Emp. Form. | C18H24O5Si |
Mol. Mass. | 348.4657 |
SMILES | [#6]-[#8]-c1ccc(cc1-[#8])[Si;v4]([#6])([#6])c1cc(-[#8]-[#6])c(-[#8]-[#6])c(-[#8]-[#6])c1 |
Structure |
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