Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50495114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1283435 (CHEMBL3107029) |
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Ki | 6.1±n/a nM |
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Citation | ?o?nowska, B; S?awi?ski, J; Pogorzelska, A; Chojnacki, J; Vullo, D; Supuran, CT Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII. Eur J Med Chem71:135-47 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50495114 |
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n/a |
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Name | BDBM50495114 |
Synonyms: | CHEMBL3104367 |
Type | Small organic molecule |
Emp. Form. | C21H22ClN5O4S3 |
Mol. Mass. | 540.078 |
SMILES | Cc1cc(c(SCc2ccccc2)cc1Cl)S(=O)(=O)NC(=N)NNc1ccc(cc1)S(N)(=O)=O |
Structure |
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