| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50042359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_52835 |
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| IC50 | >2600±n/a nM |
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| Citation |  Gangjee, A; Shi, J; Queener, SF; Barrows, LR; Kisliuk, RL Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents. J Med Chem36:3437-43 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23891.29 |
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| Organism: | Pneumocystis carinii |
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| Description: | n/a |
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| Residue: | 206 |
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| Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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| BDBM50042359 |
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| n/a |
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| Name | BDBM50042359 |
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| Synonyms: | CHEMBL114668 | N-(2,4-Diamino-5-methyl-5,8-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trimethoxy-phenyl)-formamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N6O4 |
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| Mol. Mass. | 400.4317 |
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| SMILES | COc1cc(cc(OC)c1OC)N(CC1C=Nc2nc(N)nc(N)c2C1C)C=O |c:16| |
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| Structure | 
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