| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM50042425 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_47386 |
|---|
| pH | 5.2±n/a |
|---|
| Ki | 3000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Li, Z; Patil, GS; Golubski, ZE; Hori, H; Tehrani, K; Foreman, JE; Eveleth, DD; Bartus, RT; Powers, JC Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. J Med Chem36:3472-80 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36657.87 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | Bovine spleen CB was purchased from Sigma Co. (USA). |
|---|
| Residue: | 335 |
|---|
| Sequence: | MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCG
AILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSW
NTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
|
|
|
|---|
| BDBM50042425 |
|---|
| n/a |
|---|
| Name | BDBM50042425 |
|---|
| Synonyms: | CHEMBL326290 | {1-[1-(2,2-Diphenyl-ethylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H39N3O5 |
|---|
| Mol. Mass. | 557.6799 |
|---|
| SMILES | CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
