| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Ligand | BDBM50495475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1287299 (CHEMBL3111007) |
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| IC50 | 153±n/a nM |
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| Citation |  Maltais, R; Ayan, D; Trottier, A; Barbeau, X; Lagüe, P; Bouchard, JE; Poirier, D Discovery of a non-estrogenic irreversible inhibitor of 17?-hydroxysteroid dehydrogenase type 1 from 3-substituted-16?-(m-carbamoylbenzyl)-estradiol derivatives. J Med Chem57:204-22 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
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| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34945.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14061 |
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| Residue: | 328 |
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| Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
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| BDBM50495475 |
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| n/a |
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| Name | BDBM50495475 |
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| Synonyms: | CHEMBL3108979 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36BrNO2 |
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| Mol. Mass. | 510.506 |
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| SMILES | [H][C@@]12C[C@H](Cc3cccc(c3)C(N)=O)[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(CCCBr)cc3CC[C@@]21[H] |r| |
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| Structure | 
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