| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Ligand | BDBM50042607 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_78176 |
|---|
| IC50 | 1±n/a nM |
|---|
| Citation |  Chan, C; Bailey, EJ; Hartley, CD; Hayman, DF; Hutson, JL; Inglis, GG; Jones, PS; Keeling, SE; Kirk, BE; Lamont, RB Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors. J Med Chem36:3646-57 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 96689.85 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Isolated rat liver microsomes were used as enzyme source. |
|---|
| Residue: | 887 |
|---|
| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
PKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGAS
AASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACD
SAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMIS
KGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVL
KTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
|
|
|
|---|
| BDBM50042607 |
|---|
| n/a |
|---|
| Name | BDBM50042607 |
|---|
| Synonyms: | (E)-(3R,5S)-7-[4,5-Bis-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid anion | 7-[4,5-Bis-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid | CHEMBL333760 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H26F2N2O4 |
|---|
| Mol. Mass. | 456.4817 |
|---|
| SMILES | CC(C)c1nc(c(-c2ccc(F)cc2)n1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
