| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 4 |
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| Ligand | BDBM50370584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1289589 (CHEMBL3117908) |
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| KON | 19000 M-1s-1 |
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| Citation |  Dave, K; Palzkill, T; Pratt, RF Neutral ?-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA. ACS Med Chem Lett5:154-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 4 |
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| Name: | Penicillin-binding protein 4 |
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| Synonyms: | 2.4.1.129 | 3.4.16.4 | DD-transpeptidase | PBP 4 | PBPD_BACSU | Penicillin-binding protein 4 | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | pbpD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70678.45 |
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| Organism: | Bacillus subtilis (strain 168) |
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| Description: | ChEMBL_108030 |
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| Residue: | 624 |
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| Sequence: | MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKNIDLKDISLVQNSYMYD
RDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYEHKGFDFMGMVRATASNVK
DKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQLEKKYTKNEILEAYLNTIYFN
NGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTLYDPLKHFDYTKSRQERLLKGLK
DAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYVNDEFTQLVSESEGFDKRLQKASGK
QKEKIENELSARVSTLMKDGVKIYTALDPYMQNQVVAQMNSKLPYADVQGGAAVINHQTH
QIIALSGGKNYQKYDFNRAYQAYRQPGSSIKPLLDYGPYIEQTGATTSSTIDASKFCSKD
YCPQNYNNRTYGTVTLDTAFKNSYNTPAIRMLDRVGIQKAFSYIEPYHFAKLVDSDYLLP
AALGGFTNGMTPLEMTKAYTTFGNSGSYTPSHAITKVTDLKGKTLYKWNDKATQIFSVRT
NMQLKKLMSSVVKSGTGKKAYFNAPYIGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTP
TSVEYLHSISPQLSIWKGTLQAAY
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| BDBM50370584 |
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| n/a |
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| Name | BDBM50370584 |
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| Synonyms: | Beepen-VK | Betapen-VK | PENICILLIN V | Penapar-VK | Penicillin Phenoxymethyl |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N2O5S |
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| Mol. Mass. | 350.39 |
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| SMILES | CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(O)=O |r| |
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| Structure | 
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