| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50240448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1289187 (CHEMBL3119249) |
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| Ki | 4400±n/a nM |
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| Citation |  Agapkina, J; Yanvarev, D; Anisenko, A; Korolev, S; Vepsäläinen, J; Kochetkov, S; Gottikh, M Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives. Eur J Med Chem73:73-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50240448 |
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| n/a |
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| Name | BDBM50240448 |
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| Synonyms: | 2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldiphosphonic acid | CHEMBL34249 | [2-(3,4-Dichloro-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C8H10Cl2O7P2 |
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| Mol. Mass. | 351.014 |
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| SMILES | OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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