| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50043676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_3866 (CHEMBL619382) |
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| IC50 | 45±n/a nM |
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| Citation |  Lambert-van der Brempt, C; Bruneau, P; Lamorlette, MA; Foster, SJ Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series. J Med Chem37:113-24 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | 5-LO | 5-lipoxygenase | Alox5 | Arachidonate 5-lipoxygenase | LOX5_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77961.27 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_675639 |
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| Residue: | 674 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDE
ELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLA
RDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNG
CNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDP
CTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWE
AIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPY
YYLSPDRIPNSVAI
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| BDBM50043676 |
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| n/a |
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| Name | BDBM50043676 |
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| Synonyms: | 6-[3-Fluoro-5-((S)-1-methoxy-1-methoxymethyl-propyl)-phenoxymethyl]-1-methyl-1H-quinolin-2-one | CHEMBL21651 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26FNO4 |
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| Mol. Mass. | 399.4552 |
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| SMILES | CC[C@](COC)(OC)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1 |
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| Structure | 
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