| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50034435 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_65827 (CHEMBL682960) |
|---|
| IC50 | 570±n/a nM |
|---|
| Citation |  Stein, PD; Hunt, JT; Floyd, DM; Moreland, S; Dickinson, KE; Mitchell, C; Liu, EC; Webb, ML; Murugesan, N; Dickey, J The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. J Med Chem37:329-31 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48736.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25101 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
|
|
|---|
| BDBM50034435 |
|---|
| n/a |
|---|
| Name | BDBM50034435 |
|---|
| Synonyms: | 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-2,3-dihydro-oxazol-5-yl)-amide | 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide (BMS 182874) | BMS-182874 | CHEMBL267458 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H19N3O3S |
|---|
| Mol. Mass. | 345.416 |
|---|
| SMILES | CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
