| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50034446 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65826 (CHEMBL877809) |
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| IC50 | 20000±n/a nM |
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| Citation |  Stein, PD; Hunt, JT; Floyd, DM; Moreland, S; Dickinson, KE; Mitchell, C; Liu, EC; Webb, ML; Murugesan, N; Dickey, J The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. J Med Chem37:329-31 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50034446 |
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| n/a |
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| Name | BDBM50034446 |
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| Synonyms: | CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2O3S |
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| Mol. Mass. | 302.348 |
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| SMILES | Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C |
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| Structure | 
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