Reaction Details |
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Target | Squalene monooxygenase |
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Ligand | BDBM50044100 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_202275 (CHEMBL814043) |
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IC50 | 0.87±n/a nM |
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Citation | Biftu, T; Acton, JJ; Berger, GD; Bergstrom, JD; Dufresne, C; Kurtz, MM; Marquis, RW; Parsons, WH; Rew, DR; Wilson, KE Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition. J Med Chem37:421-4 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Squalene monooxygenase |
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Name: | Squalene monooxygenase |
Synonyms: | ERG1_RAT | Erg1 | SE | Sqle |
Type: | PROTEIN |
Mol. Mass.: | 64038.00 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_505339 |
Residue: | 573 |
Sequence: | MWTFLGIATFTYFYKKCGDVTLANKELLLCVLVFLSLGLVLSYRCRHRNGGLLGRHQSGS
QFAAFSDILSALPLIGFFWAKSPPESEKKEQLESKRRRKEVNLSETTLTGAATSVSTSSV
TDPEVIIIGSGVLGSALATVLSRDGRTVTVIERDLKEPDRILGECLQPGGYRVLRELGLG
DTVESLNAHHIHGYVIHDCESRSEVQIPYPVSENNQVQSGVAFHHGKFIMSLRKAAMAEP
NVKFIEGVVLRLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKNLISNKVS
VSSHFVGFIMKDAPQFKANFAELVLVDPSPVLIYQISPSETRVLVDIRGELPRNLREYMT
EQIYPQIPDHLKESFLEACQNARLRTMPASFLPPSSVNKRGVLLLGDAYNLRHPLTGGGM
TVALKDIKIWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRSHSFVVNVLAQALYELFSATD
DSLRQLRKACFLYFKLGGECLTGPVGLLSILSPDPLLLIRHFFSVAVYATYFCFKSEPWA
TKPRALFSSGAILYKACSIIFPLIYSEMKYLVH
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BDBM50044100 |
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n/a |
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Name | BDBM50044100 |
Synonyms: | (6S,7R)-1-((R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-6-((E)-(4S,6S)-4,6-dimethyl-oct-2-enoyloxy)-4,7-dihydroxy-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid 3-benzyl ester | CHEMBL134888 |
Type | Small organic molecule |
Emp. Form. | C42H52O14 |
Mol. Mass. | 780.8539 |
SMILES | CC[C@H](C)C[C@H](C)\C=C\C(=O)O[C@H]1[C@@H](O)C2(CCC(=C)C(OC(C)=O)[C@H](C)Cc3ccccc3)OC1(C(O)=O)C(O)(C(O2)C(=O)OCc1ccccc1)C(O)=O |
Structure |
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