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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Delta-type/Kappa-type/Mu-type opioid receptor | ||
| Ligand | BDBM50019351 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1333799 (CHEMBL3231451) | ||
| EC50 | 800000±n/a nM | ||
| Citation |  Jacobson, AE; Rice, KC; Reden, J; Lupinacci, L; Brossi, A; Streaty, RA; Klee, WA Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. J Med Chem22:328-31 (1979) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Delta-type/Kappa-type/Mu-type opioid receptor | |||
| Name: | Delta-type/Kappa-type/Mu-type opioid receptor | ||
| Synonyms: | Opioid receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of ChEMBL is 1935286 | ||
| Components: | This complex has 3 components. | ||
| Component 1 | |||
| Name: | Delta-type opioid receptor | ||
| Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40465.04 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. | ||
| Residue: | 372 | ||
| Sequence: |
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| Component 2 | |||
| Name: | Kappa-type opioid receptor | ||
| Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 42692.90 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P34975 | ||
| Residue: | 380 | ||
| Sequence: |
| ||
| Component 3 | |||
| Name: | Mu-type opioid receptor | ||
| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 44503.11 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. | ||
| Residue: | 398 | ||
| Sequence: |
| ||
| BDBM50019351 | |||
| n/a | |||
| Name | BDBM50019351 | ||
| Synonyms: | (-)-Codeine | (Codeine) | (codeine)10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol | 10-methoxy-4-methyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-ol(Dihydrocodeine) | 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol | 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol phosphate(codeine) | 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol(codeine (H3PO4)) | 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol(codeine phosphate) | 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol(codeine) | 10-methoxy-4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraen-14-ol[codeine] | AMBENYL | BROMANYL | CODEINE | CODRIX | DIMETANE-DC | MYBANIL | TRIACIN-C | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H21NO3 | ||
| Mol. Mass. | 299.3642 | ||
| SMILES | COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |r,c:9| | ||
| Structure | 
| ||