| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase |
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| Ligand | BDBM50496914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1336013 (CHEMBL3238987) |
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| Ki | 33±n/a nM |
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| Citation |  Rackham, MD; Brannigan, JA; Rangachari, K; Meister, S; Wilkinson, AJ; Holder, AA; Leatherbarrow, RJ; Tate, EW Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). J Med Chem57:2773-88 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase |
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| Name: | Glycylpeptide N-tetradecanoyltransferase |
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| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase | NMT | NMT_PLAF7 | Peptide N-myristoyltransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47977.09 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_862035 |
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| Residue: | 410 |
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| Sequence: | MNDDKKDFVGRDLYQLIRNAKDKIKIDYKFWYTQPVPKINDEFDENVNEPFISDNKVEDV
RKEEYKLPSGYAWCVCDITKENDRSDIYNLLTDNYVEDDDNVFRFNYSSEFLLWALSSPN
YVKNWHIGVKYESTNKLVGFISAIPIDMCVNKNIIKMAEVNFLCVHKSLRSKRLAPVLIK
EITRRINLESIWQAIYTAGVYLPKPISTARYFHRSINVKKLIEIGFSCLNTRLTMSRAIK
LYRIDDTLNIKNLRLMKKKDIDGLQKLLNEHLKQYNLHAIFSKEDVAHWFTPIDQVIYTY
VNEENGEIKDLISFYSLPSKVLGNNKYNILNAAFSFYNITTTTTFKNLIQDAICLAKRNN
FDVFNALEVMDNYSVFQDLKFGEGDGSLKYYLYNWKCASCHPSKIGIVLL
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| BDBM50496914 |
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| n/a |
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| Name | BDBM50496914 |
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| Synonyms: | CHEMBL3237428 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N3O3S |
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| Mol. Mass. | 421.512 |
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| SMILES | COc1cccc(Cc2nnc(o2)-c2sc3ccccc3c2OC2CCNCC2)c1 |
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| Structure | 
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