Ki Summary

Reaction Details

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Target

Cholesterol side-chain cleavage enzyme, mitochondrial

Ligand

BDBM83720

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1341502 (CHEMBL3254080)

IC50

0.020±n/a nM

Citation

Elslager, EF; Hutt, MP; Jacob, P; Johnson, J; Temporelli, B; Werbel, LM; Worth, DF; Rane, L Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. J Med Chem22:1247-57 (1979) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cholesterol side-chain cleavage enzyme, mitochondrial

Name:

Cholesterol side-chain cleavage enzyme, mitochondrial

Synonyms:

CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1

Type:

PROTEIN

Mol. Mass.:

60603.33

Organism:

Rattus norvegicus

Description:

ChEMBL_50353

Residue:

526

Sequence:

MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINL
YHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYL
VPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVL
HRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFH
TSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLY
SLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQA
QGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMG
RESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENF
RIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV

BDBM83720

n/a

Name

BDBM83720

Synonyms:

6-(2-naphthalenylsulfonyl)quinazoline-2,4-diamine | 6-naphthalen-2-ylsulfonylquinazoline-2,4-diamine | MLS002920661 | SMR001798248 | WR 158122 | [2-amino-6-(2-naphthylsulfonyl)quinazolin-4-yl]amine | cid_98652

Type

Small organic molecule

Emp. Form.

C18H14N4O2S

Mol. Mass.

350.394

SMILES

Nc1nc(N)c2cc(ccc2n1)S(=O)(=O)c1ccc2ccccc2c1

Structure