| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM50044972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_217016 (CHEMBL821551) |
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| IC50 | 94000±n/a nM |
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| Citation |  Tulshian, D; Czarniecki, M; Doll, RJ; Ahn, HS Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate. J Med Chem36:1210-20 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | Heart phosphodiesterase | Phosphodiesterase 3B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 124301.20 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_156453 |
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| Residue: | 1115 |
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| Sequence: | MRRDERDAKAMRSPPPPDGAASPPESVRNGYVKGCVSPLRQDPPRGFFFHLCRFCNVELL
LPPPASPQQPRRGSPFSRARLLLGALAAFVLALLLGSGPESWAAGAARLRTLLSVCSQSL
SPLFSIACAFFFLTCFLTRTKRGAGPGRSGGGSWWLLALPACCYLGDFLVGQWESWSRGD
GDARAPVPHTPPAVAGRWFLVLSCVGLLTLAQPGRLRHSIVVLLFSSFVWWVSFTSLGAL
PPALRPLLSCLVGGVGCLLALGLDHFFQIREAPQQPQLSSTAEEKVPVIRPRRRSSCVSF
GETSGGYYGSCKMFRRPSLPCISREQMILWDWDLKQWYKPHYQISGGGSGVDLSVLNEAR
NMVSDLLVDPTLPPQVIASLRSISSLMGAFSGSCRPKMNPLTPFPGFYPCSEIEDPAEKG
DRKLHKGLNSRNSLPTPHLRRSSGTSGLPPIDQTSPRWERNNGKRPHQEFGILSQGCYLN
GPFSSNLLTVPKQRSSSVSLTHHVGLRRAGGLPSMNSPSHGPVSAGSPANRSPIEFPDTA
EFLTKPPVILHKSLSSTPNSPDFYQQLRNSDSNLCNSCGHQILKYDSASEPESGTDCHRE
KSGGEDNTVFSKASFNLTEAQQEVETENRDGRKLLWEGENHLKAAAQNEEQPNIEQEASQ
DLILIEDYDSLIENMSNWNFQIFELVEKMGEKSGRILSQVVYTLFQDTGLLEIFKIPTLQ
FMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTRPIPGLQEIHSDHGAGNETAINPER
IAYISSRSCSIPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL
YNDRSVLENHHAASAWTLYLSRPEYNFLLNLDNVEFKRFRFLVIEAILATDLKKHFDFLA
EFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPTKVRDLHLKWTEGIVNEFYEQG
DEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIESEEDDDTE
SCYEEEDAEELDTEDEEIEDNLNSKPQRRKGRRQIFCQLMHHLTENHKIWKEIIEEEEKC
KADGNKLQMENSSLPQGDEIQVIEEADEEEERQLE
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| BDBM50044972 |
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| n/a |
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| Name | BDBM50044972 |
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| Synonyms: | 5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-2-carboxymethyl-hexahydro-cyclopenta[b]furan-2-carboxylic acid | CHEMBL277926 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N5O6 |
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| Mol. Mass. | 363.3254 |
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| SMILES | Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1C[C@H]2C[C@@](CC(O)=O)(O[C@H]2C1)C(O)=O |
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| Structure | 
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