| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 48 |
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| Ligand | BDBM50497337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1442190 (CHEMBL3375263) |
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| IC50 | 180±n/a nM |
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| Citation |  Dexheimer, TS; Rosenthal, AS; Luci, DK; Liang, Q; Villamil, MA; Chen, J; Sun, H; Kerns, EH; Simeonov, A; Jadhav, A; Zhuang, Z; Maloney, DJ Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. J Med Chem57:8099-110 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 48 |
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| Name: | WD repeat-containing protein 48 |
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| Synonyms: | KIAA1449 | UAF1 | USP1-associated factor 1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 | WD repeat endosomal protein | WD repeat-containing protein 48 | WDR48 | WDR48_HUMAN | p80 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76215.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109642 |
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| Residue: | 677 |
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| Sequence: | MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN
QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYV
KALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG
TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG
QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKM
ELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGG
ASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWF
SVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVN
PMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESM
LLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHV
YEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHF
IWKSGGDLTLHYRQKST
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| BDBM50497337 |
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| n/a |
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| Name | BDBM50497337 |
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| Synonyms: | CHEMBL3187106 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N4 |
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| Mol. Mass. | 392.4956 |
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| SMILES | Cc1cnc(nc1NCc1ccc(cc1)-c1cccnc1)-c1ccccc1C1CC1 |
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| Structure | 
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