Reaction Details |
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Target | WD repeat-containing protein 48 |
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Ligand | BDBM352012 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1442190 (CHEMBL3375263) |
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IC50 | 320±n/a nM |
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Citation | Dexheimer, TS; Rosenthal, AS; Luci, DK; Liang, Q; Villamil, MA; Chen, J; Sun, H; Kerns, EH; Simeonov, A; Jadhav, A; Zhuang, Z; Maloney, DJ Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. J Med Chem57:8099-110 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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WD repeat-containing protein 48 |
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Name: | WD repeat-containing protein 48 |
Synonyms: | KIAA1449 | UAF1 | USP1-associated factor 1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 | WD repeat endosomal protein | WD repeat-containing protein 48 | WDR48 | WDR48_HUMAN | p80 |
Type: | PROTEIN |
Mol. Mass.: | 76215.66 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109642 |
Residue: | 677 |
Sequence: | MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN
QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYV
KALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG
TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG
QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKM
ELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGG
ASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWF
SVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVN
PMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESM
LLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHV
YEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHF
IWKSGGDLTLHYRQKST
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BDBM352012 |
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n/a |
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Name | BDBM352012 |
Synonyms: | US9802904, 73 |
Type | Small organic molecule |
Emp. Form. | C27H25F3N4 |
Mol. Mass. | 462.5094 |
SMILES | CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccnc(c2)C(F)(F)F)n1 |
Structure |
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