| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase |
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| Ligand | BDBM50497526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1437717 (CHEMBL3382364) |
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| IC50 | 46000±n/a nM |
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| Citation |  Altmeyer, M; Amtmann, E; Heyl, C; Marschner, A; Scheidig, AJ; Klein, CD Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg Med Chem Lett24:5310-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase |
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| Name: | Methionine aminopeptidase |
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| Synonyms: | MAP1_STAAW | MetAP | Methionine Aminopeptidase (MAP) | Peptidase M | SaMetAP-1 | map |
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| Type: | Enzyme |
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| Mol. Mass.: | 27494.40 |
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| Organism: | Staphylococcus aureus |
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| Description: | P0A079 |
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| Residue: | 252 |
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| Sequence: | MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDE
NFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQ
KVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAH
VLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTK
DGPILTTKIEEE
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| BDBM50497526 |
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| n/a |
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| Name | BDBM50497526 |
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| Synonyms: | CHEMBL3337737 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15ClF3NO |
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| Mol. Mass. | 293.713 |
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| SMILES | Cl.CN(C)CC1Cc2c(cccc2C(F)(F)F)C1=O |
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| Structure | 
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