| Reaction Details |
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 | Report a problem with these data |
| Target | M1 family aminopeptidase |
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| Ligand | BDBM50497552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438459 (CHEMBL3384271) |
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| Ki | 11±n/a nM |
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| Citation |  Mistry, SN; Drinkwater, N; Ruggeri, C; Sivaraman, KK; Loganathan, S; Fletcher, S; Drag, M; Paiardini, A; Avery, VM; Scammells, PJ; McGowan, S Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. J Med Chem57:9168-83 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| M1 family aminopeptidase |
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| Name: | M1 family aminopeptidase |
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| Synonyms: | AMPN_PLAF7 | M1AAP | Zinc aminopeptidase | m1-family aminopeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126072.31 |
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| Organism: | Plasmodium falciparum (isolate FcB1 / Columbia) |
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| Description: | ChEMBL_735637 |
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| Residue: | 1085 |
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| Sequence: | MKLTKGCAYKYIIFTVLILANILYDNKKRCMIKKNLRISSCGIISRLLKSNSNYNSFNKN
YNFTSAISELQFSNFWNLDILQKDIFSNIHNNKNKPQSYIIHKRLMSEKGDNNNNNHQNN
NGNDNKKRLGSVVNNEENTCSDKRMKPFEEGHGITQVDKMNNNSDHLQQNGVMNLNSNNV
ENNNNNNSVVVKKNEPKIHYRKDYKPSGFIINNVTLNINIHDNETIVRSVLDMDISKHNV
GEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPET
NYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKV
NEFEIPGGRHGARFNDPHLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVS
KLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKK
NSIDFSYARILTVVGHEYFHNYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTR
LSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYK
KGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNY
DAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFV
FNNIAVKPIPSLFRGFSAPVYIEDNLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNY
NEFLKAKNEKLESFNLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNL
DTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNT
LLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLL
QEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKL
IAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPNISNNLKEYLLR
LTNKL
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| BDBM50497552 |
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| n/a |
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| Name | BDBM50497552 |
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| Synonyms: | CHEMBL3359698 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15FN4O3 |
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| Mol. Mass. | 354.3351 |
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| SMILES | ONC(=O)C(NC(=O)c1ccc(F)cc1)c1ccc(cc1)-n1cccn1 |
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| Structure | 
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