| Reaction Details |
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 | Report a problem with these data |
| Target | REST corepressor 1 |
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| Ligand | BDBM50498151 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1467488 (CHEMBL3411111) |
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| IC50 | 178±n/a nM |
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| Citation |  Pieroni, M; Annunziato, G; Azzali, E; Dessanti, P; Mercurio, C; Meroni, G; Trifiró, P; Vianello, P; Villa, M; Beato, C; Varasi, M; Costantino, G Further insights into the SAR of ?-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A. Eur J Med Chem92:377-86 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| REST corepressor 1 |
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| Name: | REST corepressor 1 |
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| Synonyms: | KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53329.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108118 |
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| Residue: | 485 |
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| Sequence: | MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAAS
AAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDP
AKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEK
SLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTR
TKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEK
HSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNS
ALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV
KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVR
YASAS
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| BDBM50498151 |
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| n/a |
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| Name | BDBM50498151 |
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| Synonyms: | CHEMBL3407598 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15Cl2N |
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| Mol. Mass. | 232.15 |
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| SMILES | Cl.CC[C@]1(N)C[C@@H]1c1ccc(Cl)cc1 |r| |
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| Structure | 
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