Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50047054 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_207650 (CHEMBL811632) |
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Ki | 6±n/a nM |
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Citation | Nicolaï, E; Goyard, J; Benchetrit, T; Teulon, JM; Caussade, F; Virone, A; Delchambre, C; Cloarec, A Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem36:1175-87 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50047054 |
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n/a |
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Name | BDBM50047054 |
Synonyms: | 4-[1-(3,4-Dichloro-benzyl)-5-fluoro-1H-benzoimidazol-2-yl]-3,3-dimethyl-butyric acid | CHEMBL18257 |
Type | Small organic molecule |
Emp. Form. | C20H19Cl2FN2O2 |
Mol. Mass. | 409.281 |
SMILES | CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)c(Cl)c1 |
Structure |
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