| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50499038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1538955 (CHEMBL3737854) |
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| IC50 | >100000±n/a nM |
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| Citation |  Zhang, J; Yang, Q; Cross, JB; Romero, JA; Poutsiaka, KM; Epie, F; Bevan, D; Wang, B; Zhang, Y; Chavan, A; Zhang, X; Moy, T; Daniel, A; Nguyen, K; Chamberlain, B; Carter, N; Shotwell, J; Silverman, J; Metcalf, CA; Ryan, D; Lippa, B; Dolle, RE Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors. J Med Chem58:8503-12 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 72530.91 |
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| Organism: | Staphylococcus aureus |
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| Description: | n/a |
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| Residue: | 644 |
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| Sequence: | MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
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| BDBM50499038 |
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| n/a |
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| Name | BDBM50499038 |
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| Synonyms: | CHEMBL3736232 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16F3N7O |
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| Mol. Mass. | 427.3825 |
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| SMILES | CCNC(=O)Nc1cn(-c2ncc(cn2)C(F)(F)F)c2cc(cnc12)-c1cccnc1 |
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| Structure | 
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