Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM50048053 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_153319 |
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IC50 | 800±n/a nM |
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Citation | Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine. J Med Chem36:1847-54 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 32035.18 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 289 |
Sequence: | MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
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BDBM50048053 |
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n/a |
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Name | BDBM50048053 |
Synonyms: | 2-Amino-7-(3-trifluoromethyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL55454 |
Type | Small organic molecule |
Emp. Form. | C14H17F3N4O |
Mol. Mass. | 314.3062 |
SMILES | Nc1nc2c(CC3CCCC(C3)C(F)(F)F)c[nH]c2c(=O)[nH]1 |
Structure |
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