| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 3 |
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| Ligand | BDBM50499151 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1539745 (CHEMBL3736773) |
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| IC50 | 1200±n/a nM |
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| Citation |  Moine, E; Dimier-Poisson, I; Enguehard-Gueiffier, C; Logé, C; Pénichon, M; Moiré, N; Delehouzé, C; Foll-Josselin, B; Ruchaud, S; Bach, S; Gueiffier, A; Debierre-Grockiego, F; Denevault-Sabourin, C Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1. Eur J Med Chem105:80-105 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 3 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 3 |
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| Synonyms: | RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56886.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881455 |
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| Residue: | 518 |
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| Sequence: | MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
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| BDBM50499151 |
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| n/a |
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| Name | BDBM50499151 |
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| Synonyms: | CHEMBL3736103 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N6O |
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| Mol. Mass. | 450.5349 |
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| SMILES | COc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1 |
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| Structure | 
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