| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50499238 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1540266 (CHEMBL3739097) |
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| Ki | >1000000±n/a nM |
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| Citation |  Xu, P; Xu, M; Jiang, L; Yang, Q; Luo, Z; Dauter, Z; Huang, M; Andreasen, PA Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. J Med Chem58:8868-76 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50499238 |
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| n/a |
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| Name | BDBM50499238 |
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| Synonyms: | CHEMBL3735263 |
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| Type | Small organic molecule |
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| Emp. Form. | C58H85N17O11S2 |
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| Mol. Mass. | 1260.533 |
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| SMILES | [H][C@@]12CCCN1C(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1CCN(CC1)C(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(O)=O |r| |
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| Structure | 
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