| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50499572 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1542107 (CHEMBL3744581) |
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| IC50 | 820±n/a nM |
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| Citation |  Tandon, V; Urvashi, na; Yadav, P; Sur, S; Abbat, S; Tiwari, V; Hewer, R; Papathanasopoulos, MA; Raja, R; Banerjea, AC; Verma, AK; Kukreti, S; Bharatam, PV Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors. ACS Med Chem Lett6:1065-70 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50499572 |
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| n/a |
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| Name | BDBM50499572 |
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| Synonyms: | CHEMBL3739970 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21FN2O5 |
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| Mol. Mass. | 448.443 |
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| SMILES | COc1ccc(cc1)C1=Cc2ccc(F)cc2C(CC(=O)CO)N1c1ccc(cc1)[N+]([O-])=O |t:9| |
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| Structure | 
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