Reaction Details |
| Report a problem with these data |
Target | Legumain |
---|
Ligand | BDBM50499742 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1540559 (CHEMBL3744013) |
---|
IC50 | 169±n/a nM |
---|
Citation | Ness, KA; Eddie, SL; Higgins, CA; Templeman, A; D'Costa, Z; Gaddale, KK; Bouzzaoui, S; Jordan, L; Janssen, D; Harrison, T; Burkamp, F; Young, A; Burden, R; Scott, CJ; Mullan, PB; Williams, R Development of a potent and selective cell penetrant Legumain inhibitor. Bioorg Med Chem Lett25:5642-5 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Legumain |
---|
Name: | Legumain |
Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
Type: | n/a |
Mol. Mass.: | 49411.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 433 |
Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
|
|
|
BDBM50499742 |
---|
n/a |
---|
Name | BDBM50499742 |
Synonyms: | CHEMBL3739853 |
Type | Small organic molecule |
Emp. Form. | C21H20Cl2N4O4S |
Mol. Mass. | 495.379 |
SMILES | NC(=O)C[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(cc1Cl)-c1ccc(Cl)cc1)C#N |r| |
Structure |
|