Ki Summary

Reaction Details

Report a problem with these data

Target

Zinc metalloproteinase dpy-31

Ligand

BDBM50063917

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1541440 (CHEMBL3743608)

IC50

199526±n/a nM

Citation

France, DJ; Stepek, G; Houston, DR; Williams, L; McCormack, G; Walkinshaw, MD; Page, AP Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. Bioorg Med Chem Lett25:5752-5 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Zinc metalloproteinase dpy-31

Name:

Zinc metalloproteinase dpy-31

Synonyms:

3.4.24.- | NAS35_BRUMA | Nematode astacin 35 | Procollagen C-proteinase | Zinc metalloproteinase dpy-31 | dpy-31 | nas-35

Type:

PROTEIN

Mol. Mass.:

68969.76

Organism:

Brugia malayi

Description:

ChEMBL_116692

Residue:

599

Sequence:

MALLKPFLSRTFSSFFATITGGRNLIDSIEELITTNYWLIFVMIIVCTCSAPSNGAFFLN
DPYGYPFVSLQDDSIESVSATTITTTTIISTIITTTTATQRIFQEKAKTFGQSAEEIQKV
KYYLEKIQKFEAKQHPEEIRQQHTTKNSEAIKDDLQIAVEVAKFEKRQKDSITLNPEENG
QYYEGDIVLDAQQAHEIYESMIQHGRRTKRKFIRSELRRWDSHKPIIYSFDGSHTIREQR
VIELALEHWHNITCLNFERRDDEIQENRIVFTDVDGCASNVGRHPLGEPQFVSLAPECIR
LGVIAHEVAHALGFWHEQSRPDRDNYVTVRWENIDRDSKGQFLKELPTDVDNGDVPYDYG
SIMHYRSKAFGRYEDLFTLNTNIMDYQKTIGQRDQLSFNDIRLMNVIYCSDSCAQKLPCQ
RGGYTDPRRCGRCRCPDGFTGKLCERIMPGFGADCGGRIELTSSWKRITSPNYPRDFKEG
QECSWLLVAPPGQRVQLRFYGEFEMYCKVRHSLCMDYIEIRNSTDFANTGMRYCCYGTPK
SSIMSATEDMLVLFRSFYRGGKGFQAQVRALPTTVFNIRTVRSMDEFNANLNKHAVADS

BDBM50063917

n/a

Name

BDBM50063917

Synonyms:

(2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide | CHEMBL279785 | cid_119031 | marimastat

Type

Small organic molecule

Emp. Form.

C15H29N3O5

Mol. Mass.

331.4079

SMILES

CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C |r|

Structure