| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50499870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1541732 (CHEMBL3745240) |
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| Ki | 14±n/a nM |
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| Citation |  Das, B; Vedachalam, S; Luo, D; Antonio, T; Reith, ME; Dutta, AK Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease. J Med Chem58:9179-95 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 |
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| Type: | Protein |
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| Mol. Mass.: | 49540.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P19020 |
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| Residue: | 446 |
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| Sequence: | MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
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| BDBM50499870 |
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| n/a |
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| Name | BDBM50499870 |
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| Synonyms: | CHEMBL3740778 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29ClF3N7O2S |
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| Mol. Mass. | 584.057 |
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| SMILES | OC(=O)C(F)(F)F.Nc1nc2CC[C@@H](Cc2s1)N(CCN1CCN(CC1)c1ccc2[nH]ccc2c1Cl)CC#N |r| |
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| Structure | 
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