Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Carbonic anhydrase 12 | ||
| Ligand | BDBM50500056 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1541758 (CHEMBL3745440) | ||
| Ki | 7.0±n/a nM | ||
| Citation |  Carta, F; Ferraroni, M; Scozzafava, A; Supuran, CT Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies. Bioorg Med Chem24:104-12 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Carbonic anhydrase 12 | |||
| Name: | Carbonic anhydrase 12 | ||
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 39456.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Catalytic domain of human cloned isozyme was used in the assay | ||
| Residue: | 354 | ||
| Sequence: |
| ||
| BDBM50500056 | |||
| n/a | |||
| Name | BDBM50500056 | ||
| Synonyms: | CHEMBL3741011 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H21N3O7S2 | ||
| Mol. Mass. | 575.612 | ||
| SMILES | NS(=O)(=O)c1ccc(CNC(=S)Nc2ccc(c(c2)C(O)=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)cc1 |(-2.69,18.17,;-2.69,16.94,;-3.75,17.56,;-1.62,17.56,;-2.69,15.4,;-4.02,14.63,;-4.02,13.09,;-2.68,12.32,;-2.68,10.78,;-1.34,10.01,;-1.34,8.47,;-2.4,7.85,;-0,7.7,;0,6.16,;-1.33,5.39,;-1.33,3.85,;0,3.08,;1.34,3.85,;1.34,5.39,;2.67,3.09,;2.68,2.06,;3.74,3.7,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-4,-.77,;-5.07,-1.39,;-2.67,-1.54,;-1.33,-.77,;,-1.54,;1.31,-.77,;2.67,-1.54,;4,-.77,;5.07,-1.39,;4,.77,;2.67,1.54,;1.31,.77,;-1.35,13.09,;-1.35,14.63,)| | ||
| Structure | 
| ||