| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
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| Ligand | BDBM50049696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_123285 (CHEMBL732386) |
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| IC50 | 200±n/a nM |
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| Citation |  Harfenist, M; Heuser, DJ; Joyner, CT; Batchelor, JF; White, HL Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups. J Med Chem39:1857-63 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A |
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| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59515.21 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 526 |
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| Sequence: | MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV
KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA
YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI
NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL
SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM
GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR
QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD
VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
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| BDBM50049696 |
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| n/a |
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| Name | BDBM50049696 |
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| Synonyms: | 6-(4,5-Dihydro-1H-imidazol-2-yl)-2-fluoro-10,10-dioxo-10H-10lambda*6*-thioxanthen-9-one | CHEMBL55927 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11FN2O3S |
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| Mol. Mass. | 330.334 |
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| SMILES | Fc1ccc2c(c1)C(=O)c1ccc(cc1S2(=O)=O)C1=NCCN1 |t:21| |
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| Structure | 
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