Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
Ligand | BDBM50500412 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1546366 (CHEMBL3748597) | ||
Ki | 141±n/a nM | ||
Citation | Ouach, A; Pin, F; Bertrand, E; Vercouillie, J; Gulhan, Z; Mothes, C; Deloye, JB; Guilloteau, D; Suzenet, F; Chalon, S; Routier, S Design of ?7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies. Eur J Med Chem107:153-64 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-7 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56502.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q05941 | ||
Residue: | 502 | ||
Sequence: |
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BDBM50500412 | |||
n/a | |||
Name | BDBM50500412 | ||
Synonyms: | CHEMBL3746710 | ||
Type | Small organic molecule | ||
Emp. Form. | C14H17N5 | ||
Mol. Mass. | 255.3183 | ||
SMILES | C1CN2CCC1[C@H](C2)n1cc(nn1)-c1ccncc1 |r,wD:6.9,(5.21,-2.38,;5.21,-4.01,;3.81,-4.83,;4.33,-3.38,;3.26,-2.74,;3.81,-1.57,;2.43,-2.41,;2.41,-4.03,;1.05,-1.6,;.92,-.08,;-.59,.25,;-1.37,-1.07,;-.35,-2.23,;-1.2,1.67,;-.39,2.97,;-1.11,4.33,;-2.65,4.39,;-3.47,3.08,;-2.75,1.72,)| | ||
Structure |