| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA gyrase subunit B |
|---|
| Ligand | BDBM50500627 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1549298 (CHEMBL3758003) |
|---|
| IC50 | 7400±n/a nM |
|---|
| Citation |  Medapi, B; Meda, N; Kulkarni, P; Yogeeswari, P; Sriram, D Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors. Bioorg Med Chem24:877-85 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA gyrase subunit B |
|---|
| Name: | DNA gyrase subunit B |
|---|
| Synonyms: | 5.6.2.2 | DNA gyrase subunit B | GYRB_MYCTU | gyrB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 74087.83 |
|---|
| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
|---|
| Description: | ChEMBL_109655 |
|---|
| Residue: | 675 |
|---|
| Sequence: | MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV
|
|
|
|---|
| BDBM50500627 |
|---|
| n/a |
|---|
| Name | BDBM50500627 |
|---|
| Synonyms: | CHEMBL3752277 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H21N5O3 |
|---|
| Mol. Mass. | 463.4873 |
|---|
| SMILES | Cc1ccc2nc3ccccc3c(Nc3ccc(NC(=O)Nc4ccc(cc4)[N+]([O-])=O)cc3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
