Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50500648 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1549298 (CHEMBL3758003) |
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IC50 | 10400±n/a nM |
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Citation | Medapi, B; Meda, N; Kulkarni, P; Yogeeswari, P; Sriram, D Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors. Bioorg Med Chem24:877-85 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | 5.6.2.2 | DNA gyrase subunit B | GYRB_MYCTU | gyrB |
Type: | PROTEIN |
Mol. Mass.: | 74087.83 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | ChEMBL_109655 |
Residue: | 675 |
Sequence: | MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV
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BDBM50500648 |
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n/a |
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Name | BDBM50500648 |
Synonyms: | CHEMBL3753342 |
Type | Small organic molecule |
Emp. Form. | C26H19ClN4O |
Mol. Mass. | 438.908 |
SMILES | Clc1ccc(NC(=O)Nc2ccc(Nc3c4ccccc4nc4ccccc34)cc2)cc1 |
Structure |
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