| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
|---|
| Ligand | BDBM50380884 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1572951 (CHEMBL3801461) |
|---|
| Ki | 3.2±n/a nM |
|---|
| Citation |  Shukla, L; Ajram, LA; Begg, M; Evans, B; Graves, RH; Hodgson, ST; Lynn, SM; Miah, AH; Percy, JM; Procopiou, PA; Richards, SA; Slack, RJ 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. Eur J Med Chem115:14-25 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 4 |
|---|
| Name: | C-C chemokine receptor type 4 |
|---|
| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41406.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51679 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
|
|
|
|---|
| BDBM50380884 |
|---|
| n/a |
|---|
| Name | BDBM50380884 |
|---|
| Synonyms: | CHEMBL2018954 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27BrN4O5S |
|---|
| Mol. Mass. | 551.453 |
|---|
| SMILES | COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
