Reaction Details |
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Target | C-C chemokine receptor type 4 |
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Ligand | BDBM50500895 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1572955 (CHEMBL3801465) |
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EC50 | 398±n/a nM |
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Citation | Shukla, L; Ajram, LA; Begg, M; Evans, B; Graves, RH; Hodgson, ST; Lynn, SM; Miah, AH; Percy, JM; Procopiou, PA; Richards, SA; Slack, RJ 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. Eur J Med Chem115:14-25 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 4 |
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Name: | C-C chemokine receptor type 4 |
Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
Type: | Enzyme |
Mol. Mass.: | 41406.41 |
Organism: | Homo sapiens (Human) |
Description: | P51679 |
Residue: | 360 |
Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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BDBM50500895 |
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n/a |
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Name | BDBM50500895 |
Synonyms: | CHEMBL3797462 |
Type | Small organic molecule |
Emp. Form. | C27H32ClFN6O3 |
Mol. Mass. | 543.033 |
SMILES | COc1cc2nc(nc(Nc3ccc(Cl)cc3F)c2cc1OC)N1CCC(CC1)N(C)C(=O)[C@H]1CCCN1 |r| |
Structure |
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