Reaction Details |
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Target | C-C chemokine receptor type 4 |
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Ligand | BDBM50500912 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1572951 (CHEMBL3801461) |
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Ki | 126±n/a nM |
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Citation | Shukla, L; Ajram, LA; Begg, M; Evans, B; Graves, RH; Hodgson, ST; Lynn, SM; Miah, AH; Percy, JM; Procopiou, PA; Richards, SA; Slack, RJ 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. Eur J Med Chem115:14-25 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 4 |
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Name: | C-C chemokine receptor type 4 |
Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
Type: | Enzyme |
Mol. Mass.: | 41406.41 |
Organism: | Homo sapiens (Human) |
Description: | P51679 |
Residue: | 360 |
Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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BDBM50500912 |
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n/a |
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Name | BDBM50500912 |
Synonyms: | CHEMBL3797946 |
Type | Small organic molecule |
Emp. Form. | C26H30Cl2F6N6O5 |
Mol. Mass. | 691.45 |
SMILES | OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CNCC(=O)N1CCC2(C1)CCN(CC2)c1nccc(NCc2ccc(Cl)cc2Cl)n1 |
Structure |
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