Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50051161 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63975 (CHEMBL677601) |
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Ki | 230±n/a nM |
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Citation | Edwards, PD; Andisik, DW; Strimpler, AM; Gomes, B; Tuthill, PA Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones. J Med Chem39:1112-24 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50051161 |
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n/a |
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Name | BDBM50051161 |
Synonyms: | CHEMBL276181 | N-(3,3,3-Trifluoro-1-isopropyl-2-oxo-propyl)-2-[(R)-2,4,8-trioxo-3-((1S,2R)-2-phenyl-cyclopropyl)-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide |
Type | Small organic molecule |
Emp. Form. | C24H23F3N4O5 |
Mol. Mass. | 504.4584 |
SMILES | CC(C)C(NC(=O)Cn1ccc2c([nH]c(=O)n([C@H]3C[C@@H]3c3ccccc3)c2=O)c1=O)C(=O)C(F)(F)F |
Structure |
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